The Shrier lab is interested in ion channel function and cardiac dynamics, studying the molecular mechanisms that underlie the quality control and regulation of hERG and TRPM7 channels, respectively. Optical dyes are used to image the conduction of the cardiac impulse in patterned cultured cardiac myocytes, analyzed and modeled using nonlinear mathematical techniques. The aim is to understand the origin and termination of abnormal rhythms that occur in the heart and other excitable systems.