Research in the Mittermaier lab is focused on understanding protein and nucleic acid function at the atomic level. Researchers combine site-specific information on macromolecular motions gained from high-field solution state NMR spectroscopy with detailed thermodynamic information yielded by calorimetry and other biophysical techniques. This combined approach elucidates the mechanisms underlying a variety of fundamental biological phenomena including folding, catalysis and allostery, with applications to drug design, protein and nucleic acid engineering, and biologics development.